Nursing profession is known to be highly stressful occupation especially mental health nurses which will affect the physical and mental health of nurses. Studies have shown that those who have high levels of resilience are less likely to develop stress disorders and more likely to remain in the profession as healthy nurses. Both occupational stress and resilience may vary based on their gender and locality where they are working. This study aims to explore the relationship between job stress and resilience among male and female mental health nurses working in Urban and Rural areas of Calicut district. Participants included 75 nurses who were selected through a stratified random sampling method from different parts of Calicut district. The data were collected using occupational Stress Index by A.K Srivastava and A.P Singh (1981) and Resilience Scale (RS), created by Waglindand Young (1993) and were analysed using Pearson’s Product Moment Correlation Coefficient and t-test. The findings revealed that resilience and occupational stress are correlated. It was also depicted that there is a significant difference in job stress and resilience based on the gender (Male & Female) of nurses and the locality (Urban & Rural) of their working place.